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Tobacco Use Statistics: Digging Into the Data Tobacco use is the leading preventable cause of disease, disability, and death in the U.S., accounting for over 480,000 deaths annually

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Nearly half of all former smokers have quit, 12 cigarette sales declined to a third of what they once were, and the death rate from lung cancer declined

"FDA's review of modified risk products is intended to ensure that adult users have clear, science-based information about the relative harms of tobacco products, so they can make informed choices," Bret Koplow, acting director of the FDA's Center for Tobacco Products, said in a statement